3d7z Summary


Crystal Structure of P38 Kinase in Complex with a biphenyl amide inhibitor

The structure was published by Angell, R., Aston, N.M., Bamborough, P., et al., Smith, K.J., Somers, D.O., and Walker, A.L., in 2008 in a paper entitled "Biphenyl amide p38 kinase inhibitors 3: Improvement of cellular and in vivo activity." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 360 residues which is 100% of the natural sequence. Out of 360 residues 349 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 Q16539 (1-360) (MK14_HUMAN)search Homo sapienssearch 97% 360 96%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (1 - 360) Mitogen-activated protein kinase 14 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (Q16539) transferase activity, transferring phosphorus-containing groupssearch protein bindingsearch MAP kinase kinase activitysearch MAP kinase activitysearch protein serine/threonine kinase activitysearch protein kinase activitysearch ATP bindingsearch kinase activitysearch transferase activitysearch NFAT protein bindingsearch nucleotide bindingsearch MyD88-independent toll-like receptor signaling pathwaysearch neurotrophin TRK receptor signaling pathwaysearch blood coagulationsearch protein phosphorylationsearch muscle cell differentiationsearch fatty acid oxidationsearch positive regulation of myoblast differentiationsearch transcription, DNA-templatedsearch myoblast differentiation involved in skeletal muscle regenerationsearch MyD88-dependent toll-like receptor signaling pathwaysearch regulation of transcription from RNA polymerase II promotersearch p38MAPK cascadesearch toll-like receptor TLR6:TLR2 signaling pathwaysearch cellular response to DNA damage stimulussearch positive regulation of transcription from RNA polymerase II promotersearch DNA damage checkpointsearch toll-like receptor 3 signaling pathwaysearch response to muramyl dipeptidesearch cellular response to lipopolysaccharidesearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch positive regulation of myotube differentiationsearch platelet activationsearch toll-like receptor 9 signaling pathwaysearch osteoclast differentiationsearch gene expressionsearch stress-activated MAPK cascadesearch positive regulation of myoblast fusionsearch skeletal muscle tissue developmentsearch 3'-UTR-mediated mRNA stabilizationsearch signal transduction in response to DNA damagesearch toll-like receptor 4 signaling pathwaysearch peptidyl-serine phosphorylationsearch chondrocyte differentiationsearch angiogenesissearch phosphorylationsearch cellular response to ionizing radiationsearch toll-like receptor 5 signaling pathwaysearch TRIF-dependent toll-like receptor signaling pathwaysearch positive regulation of muscle cell differentiationsearch regulation of transcription, DNA-templatedsearch vascular endothelial growth factor receptor signaling pathwaysearch RNA metabolic processsearch glucose metabolic processsearch positive regulation of protein import into nucleussearch stress-induced premature senescencesearch striated muscle cell differentiationsearch positive regulation of blood vessel endothelial cell migrationsearch toll-like receptor signaling pathwaysearch apoptotic processsearch cellular response to vascular endothelial growth factor stimulussearch toll-like receptor 10 signaling pathwaysearch regulation of sequence-specific DNA binding transcription factor activitysearch positive regulation of erythrocyte differentiationsearch lipopolysaccharide-mediated signaling pathwaysearch response to lipopolysaccharidesearch toll-like receptor TLR1:TLR2 signaling pathwaysearch cartilage condensationsearch cell surface receptor signaling pathwaysearch innate immune responsesearch cell morphogenesissearch negative regulation of canonical Wnt signaling pathwaysearch cellular component movementsearch mRNA metabolic processsearch toll-like receptor 2 signaling pathwaysearch response to stresssearch activation of MAPK activitysearch Ras protein signal transductionsearch chemotaxissearch signal transductionsearch positive regulation of reactive oxygen species metabolic processsearch intracellular signal transductionsearch cytosolsearch mitochondrionsearch spindle polesearch nucleoplasmsearch cytoplasmsearch nucleussearch extracellular vesicular exosomesearch cellsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch