EC 2.7.11.24: Mitogen-activated protein kinase
Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Systematic name:
ATP:protein phosphotransferase (MAPKK-activated)
Alternative Name(s):
- C-Jun N-terminal kinase
- Dp38
- ERK
- ERK1
- ERK2
- Extracellular signal-regulated kinase
- JNK
- JNK3-alpha-1
- LeMPK3
- MAP kinase
- MAP-2 kinase
- MAPK
- MBP kinase I
- MBP kinase II
- Microtubule-associated protein 2 kinase
- Microtubule-associated protein kinase
- Myelin basic protein kinase
- P38-2
- P38-delta
- P42 mitogen-activated protein kinase
- P42(mapk)
- P44mpk
- PMK-1
- PMK-2
- PMK-3
- Pp42
- Pp44(mapk)
- SAPK
- STK26
- Stress-activated protein kinase
GO terms
Biochemical function:
- protein serine kinase activity
- NFAT protein binding
- mitogen-activated protein kinase p38 binding
- protein phosphatase binding
- enzyme binding
- transferase activity
- kinase activity
- ATP binding
- protein binding
- MAP kinase kinase activity
- MAP kinase activity
- protein serine/threonine kinase activity
- protein kinase activity
- nucleotide binding
Biological process:
- positive regulation of reactive oxygen species metabolic process
- positive regulation of myoblast fusion
- regulation of cytokine production involved in inflammatory response
- regulation of synaptic membrane adhesion
- cellular response to virus
- stress-induced premature senescence
- cellular senescence
- positive regulation of brown fat cell differentiation
- negative regulation of canonical Wnt signaling pathway
- cellular response to UV-B
- cellular response to ionizing radiation
- cellular response to tumor necrosis factor
- cellular response to lipoteichoic acid
- cellular response to lipopolysaccharide
- 3'-UTR-mediated mRNA stabilization
- bone development
- positive regulation of cardiac muscle cell proliferation
- stress-activated MAPK cascade
- positive regulation of muscle cell differentiation
- striated muscle cell differentiation
- stem cell differentiation
- vascular endothelial growth factor receptor signaling pathway
- positive regulation of glucose import
- glucose import
- positive regulation of transcription by RNA polymerase II
- positive regulation of myoblast differentiation
- positive regulation of erythrocyte differentiation
- positive regulation of blood vessel endothelial cell migration
- signal transduction in response to DNA damage
- positive regulation of protein import into nucleus
- p38MAPK cascade
- response to muscle stretch
- cellular response to vascular endothelial growth factor stimulus
- intracellular signal transduction
- negative regulation of hippo signaling
- cellular response to stress
- response to insulin
- positive regulation of interleukin-12 production
- response to lipopolysaccharide
- response to muramyl dipeptide
- lipopolysaccharide-mediated signaling pathway
- positive regulation of cyclase activity
- stress-activated protein kinase signaling cascade
- osteoclast differentiation
- regulation of ossification
- platelet activation
- fatty acid oxidation
- peptidyl-serine phosphorylation
- phosphorylation
- positive regulation of myotube differentiation
- positive regulation of gene expression
- skeletal muscle tissue development
- cell surface receptor protein serine/threonine kinase signaling pathway
- cell surface receptor signaling pathway
- signal transduction
- DNA damage response
- chemotaxis
- apoptotic process
- protein phosphorylation
- transcription by RNA polymerase II
- regulation of transcription by RNA polymerase II
- regulation of DNA-templated transcription
- glucose metabolic process
- negative regulation of inflammatory response to antigenic stimulus
- chondrocyte differentiation
- response to dietary excess
- placenta development
- osteoblast differentiation
- angiogenesis
- cartilage condensation
- cell morphogenesis
- MAPK cascade
- DNA damage checkpoint signaling
Cellular component:
Sequence family
Protein family (Pfam)
InterPro annotations
Structure domains
CATH domains
1.10.510.10
Class:
Mainly Alpha
Architecture:
Orthogonal Bundle
Topology:
Transferase(Phosphotransferase); domain 1
Homology:
Transferase(Phosphotransferase) domain 1
Occurring in:
SCOP annotation