3d7u Summary

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Structural basis for the recognition of c-Src by its inactivator Csk

The structure was published by Levinson, N.M., Seeliger, M.A., Cole, P.A., and Kuriyan, J., in 2008 in a paper entitled "Structural basis for the recognition of c-Src by its inactivator Csk." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 4.111 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Tyrosine-protein kinase CSK and Proto-oncogene tyrosine-protein kinase Src.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Tyrosine-protein kinase CSK P41240 (188-450) (CSK_HUMAN)search Homo sapienssearch < 90% 263 97%
C Tyrosine-protein kinase CSK P41240 (188-450) (CSK_HUMAN)search Homo sapienssearch < 90% 263 97%
B Proto-oncogene tyrosine-protein kinase Src P00523 (260-523) (SRC_CHICK)search Gallus gallussearch < 90% 277 93%
D Proto-oncogene tyrosine-protein kinase Src P00523 (260-523) (SRC_CHICK)search Gallus gallussearch < 90% 277 93%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P41240 (188 - 450) Tyrosine-protein kinase CSK Homo sapiens
P00523 (260 - 523) Proto-oncogene tyrosine-protein kinase Src Gallus gallus

Chain Structural classification (SCOP) Sequence family (Pfam)
A, C Protein kinases, catalytic subunitsearch Protein tyrosine kinasesearch
B, D Protein tyrosine kinasesearch
Chain InterPro annotation
A, C Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch
B, D Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch