3d5f Summary


Crystal Structure of PPAR-delta complex

The structure was published by Iwashita, A., Mihara, K., Amano, Y., Orita, M., and Matsuoka, N., in in a paper entitled "PPAR-Delta Activation Contributes to Neuroprotectio Against Thapsigargin-Induced SH-SY5Y Cell Death" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Peroxisome proliferator-activated receptor delta.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Peroxisome proliferator-activated receptor delta Q03181 (175-441) (PPARD_HUMAN)search Homo sapienssearch < 90% 267 95%
B Peroxisome proliferator-activated receptor delta Q03181 (175-441) (PPARD_HUMAN)search Homo sapienssearch < 90% 267 95%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q03181 (175 - 441) Peroxisome proliferator-activated receptor delta Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (Q03181) steroid hormone mediated signaling pathwaysearch regulation of transcription, DNA-templatedsearch ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activitysearch DNA bindingsearch sequence-specific DNA binding transcription factor activitysearch steroid hormone receptor activitysearch nucleussearch

Chain InterPro annotation
A, B Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Peroxisome proliferator-activated receptorsearch Peroxisome proliferator-activated receptor, betasearch Nuclear hormone receptor, ligand-bindingsearch