3d57 Summary


TR Variant D355R

The structure was published by Jouravel, N., Sablin, E., Togashi, M., Baxter, J.D., Webb, P., and Fletterick, R.J., in 2008 in a paper entitled "Molecular basis for dimer formation of TRbeta variant D355R." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Thyroid hormone receptor beta.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Thyroid hormone receptor beta P10828 (209-460) (THB_HUMAN)search Homo sapienssearch < 90% 266 93%
B Thyroid hormone receptor beta P10828 (209-460) (THB_HUMAN)search Homo sapienssearch < 90% 266 93%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P10828 (209 - 460) Thyroid hormone receptor beta Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B (P10828) DNA bindingsearch thyroid hormone receptor activitysearch steroid hormone receptor activitysearch sequence-specific DNA binding transcription factor activitysearch nucleussearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch

Chain InterPro annotation
A, B Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Thyroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch