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PDBe Entry: 3d51 view

GOLGI MANNOSIDASE II complex with gluco-hydroxyiminolactam
Summary
Header HYDROLASEsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 1.43 Å, R-factor: 18.7%, Free R-factor: 20.1%, Spacegroup: P 21 21 21
Released 05/08/2008, deposition: 15/05/2008, last revision: 24/02/2009
Authors Kuntz, D.A.search; Tarling, C.A.search; Withers, S.G.search; Rose, D.R.search
Primary citation Structural analysis of Golgi alpha-mannosidase II inhibitors identified from a focused glycosidase inhibitor screen.
BIOCHEMISTRYsearch vol:47, pag:10058-10068 (2008) [PubMed ID 18759458 ]search
Keywords GH38 Glycosidasesearch, HYDROLASEsearch
EC 3.2.1.114 ExPASy BRENDA search (A)
Organism Drosophila melanogaster(fruit fly) 7227search(A)
UniProt Alpha-mannosidase 2 (EC 3.2.1.114) (Alpha-mannosidase II) (AMAN II) (MAN II) (Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase) (Golgi alpha-mannosidase II) Q24451search (A)
Solvent A
Related entries 1hty, 1hww, 1hxk, 1ps2, 1qwn, 1qwu, 1qx1, 1r33, 1r34, 2alw, 2f7o, 2f7p, 2f7q, 2f7r, 3bub, 3bud, 3bui, 3bup, 3buq, 3bvt, 3bvu, 3bvv, 3bvw, 3bvx, 3cv5, 3czn, 3czs, 3d4y, 3d4z, 3d50, 3d52
Polymers
Id Name Type UniProt Residues Observed
A Alpha-mannosidase 2 Protein Q24451 (MAN2_DROME)search
1045 97%
Heterogens
Id Name Ligands
A ZINC ION ZN search
A (4R)-2-METHYLPENTANE-2,4-DIOL MRD search
A (2S,3S,4R,5R)-6-(HYDROXYAMINO)-2-(HYDROXYMETHYL)-2,3,4,5-TETRAHYDROPYRIDINE-3,4,5-TRIOL GOX search
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