3d4q Summary

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Pyrazole-based inhibitors of B-Raf kinase

The structure was published by Hansen, J.D., Grina, J., Newhouse, B., et al., Randolph, N., Lyssikatos, J., and Olivero, A., in 2008 in a paper entitled "Potent and selective pyrazole-based inhibitors of B-Raf kinase." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of B-Raf proto-oncogene serine/threonine-protein kinase.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A B-Raf proto-oncogene serine/threonine-protein kinase P15056 (433-726) (BRAF_HUMAN)search Homo sapienssearch < 90% 307 85%
B B-Raf proto-oncogene serine/threonine-protein kinase P15056 (433-726) (BRAF_HUMAN)search Homo sapienssearch < 90% 307 85%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P15056 (433 - 726) B-Raf proto-oncogene serine/threonine-protein kinase Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Biological process (GO) Molecular function (GO)
A, B (P15056) protein phosphorylationsearch protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch ATP bindingsearch protein kinase activitysearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch