3d0y Summary

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Crystal Structure of S100B in the Calcium and Zinc Loaded State at pH 6.5

The structure was published by Ostendorp, T., Diez, J., Heizmann, C.W., and Fritz, G., in 2011 in a paper entitled "The crystal structures of human S100B in the zinc- and calcium-loaded state at three pH values reveal zinc ligand swapping." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.5 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Protein S100-B.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Protein S100-B P04271 (1-92) (S100B_HUMAN)search Homo sapienssearch 99% 92 97%
B Protein S100-B P04271 (1-92) (S100B_HUMAN)search Homo sapienssearch 99% 92 97%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P04271 (1 - 92) Protein S100-B Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P04271) EF-handsearch PF01023: S-100/ICaBP type calcium binding domainsearch
B (P04271) EF-handsearch PF01023: S-100/ICaBP type calcium binding domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P04271) calcium ion bindingsearch S100 protein bindingsearch protein bindingsearch RAGE receptor bindingsearch protein homodimerization activitysearch metal ion bindingsearch identical protein bindingsearch tau protein bindingsearch zinc ion bindingsearch receptor bindingsearch calcium-dependent protein bindingsearch positive regulation of cell proliferationsearch axonogenesissearch positive regulation of I-kappaB kinase/NF-kappaB signalingsearch negative regulation of skeletal muscle cell differentiationsearch regulation of neuronal synaptic plasticitysearch central nervous system developmentsearch cellular response to hypoxiasearch astrocyte differentiationsearch regulation of cell shapesearch memorysearch long-term synaptic potentiationsearch response to glucocorticoidsearch cell proliferationsearch innate immune responsesearch learning or memorysearch response to methylmercurysearch positive regulation of synaptic transmissionsearch positive regulation of apoptotic processsearch perinuclear region of cytoplasmsearch nucleussearch cytoplasmsearch extracellular regionsearch neuronal cell bodysearch intracellular membrane-bounded organellesearch rufflesearch extracellular spacesearch
B (P04271) calcium ion bindingsearch protein homodimerization activitysearch protein bindingsearch metal ion bindingsearch S100 protein bindingsearch identical protein bindingsearch zinc ion bindingsearch calcium-dependent protein bindingsearch tau protein bindingsearch RAGE receptor bindingsearch receptor bindingsearch learning or memorysearch memorysearch positive regulation of synaptic transmissionsearch long-term synaptic potentiationsearch axonogenesissearch innate immune responsesearch positive regulation of apoptotic processsearch regulation of cell shapesearch astrocyte differentiationsearch cellular response to hypoxiasearch positive regulation of cell proliferationsearch cell proliferationsearch central nervous system developmentsearch response to glucocorticoidsearch regulation of neuronal synaptic plasticitysearch response to methylmercurysearch positive regulation of I-kappaB kinase/NF-kappaB signalingsearch negative regulation of skeletal muscle cell differentiationsearch extracellular regionsearch cytoplasmsearch extracellular spacesearch rufflesearch nucleussearch intracellular membrane-bounded organellesearch perinuclear region of cytoplasmsearch neuronal cell bodysearch

Chain InterPro annotation
A S100/Calbindin-D9k, conserved sitesearch EF-hand domainsearch EF-hand domain pairsearch S100/CaBP-9k-type, calcium binding, subdomainsearch EF-Hand 1, calcium-binding sitesearch Protein S100-Bsearch
B S100/Calbindin-D9k, conserved sitesearch EF-hand domainsearch EF-hand domain pairsearch S100/CaBP-9k-type, calcium binding, subdomainsearch EF-Hand 1, calcium-binding sitesearch Protein S100-Bsearch