3cza Summary

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Crystal Structure of E18D DJ-1

The structure was published by Witt, A.C., Lakshminarasimhan, M., Remington, B.C., Hasim, S., Pozharski, E., and Wilson, M.A., in 2008 in a paper entitled "Cysteine pKa depression by a protonated glutamic acid in human DJ-1." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.2 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Protein DJ-1. This molecule has the UniProt identifier Q99497 (PARK7_HUMAN)search. The sample contained 197 residues which is 100% of the natural sequence. Out of 197 residues 186 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Protein DJ-1 Q99497 (1-189) (PARK7_HUMAN)search Homo sapienssearch 99% 197 94%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q99497 (1 - 189) Protein DJ-1 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (Q99497) Rossmann foldsearch PF01965: DJ-1/PfpI familysearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (Q99497) protein bindingsearch enzyme bindingsearch ubiquitin-specific protease bindingsearch protein homodimerization activitysearch cuprous ion bindingsearch small protein activating enzyme bindingsearch core promoter bindingsearch peptidase activitysearch glyoxalase III activitysearch identical protein bindingsearch double-stranded DNA bindingsearch scaffold protein bindingsearch superoxide dismutase copper chaperone activitysearch peroxiredoxin activitysearch repressing transcription factor bindingsearch cytokine bindingsearch glyoxalase (glycolic acid-forming) activitysearch peroxidase activitysearch mRNA bindingsearch transcription factor bindingsearch RNA bindingsearch transcription coactivator activitysearch tyrosine 3-monooxygenase activator activitysearch small protein conjugating enzyme bindingsearch androgen receptor bindingsearch L-dopa decarboxylase activator activitysearch oxidoreductase activity, acting on peroxide as acceptorsearch receptor bindingsearch cupric ion bindingsearch single-stranded DNA bindingsearch hydrolase activitysearch regulation of mitochondrial membrane potentialsearch negative regulation of protein bindingsearch mitochondrion organizationsearch negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathwaysearch positive regulation of mitochondrial electron transport, NADH to ubiquinonesearch positive regulation of L-dopa decarboxylase activitysearch single fertilizationsearch negative regulation of extrinsic apoptotic signaling pathwaysearch glyoxal catabolic processsearch positive regulation of transcription from RNA polymerase II promotersearch regulation of inflammatory responsesearch positive regulation of superoxide dismutase activitysearch hydrogen peroxide metabolic processsearch glycolate biosynthetic processsearch positive regulation of interleukin-8 productionsearch autophagysearch lactate biosynthetic processsearch negative regulation of ubiquitin-specific protease activitysearch methylglyoxal catabolic process to D-lactatesearch positive regulation of L-dopa biosynthetic processsearch cellular response to oxidative stresssearch synaptic transmission, dopaminergicsearch negative regulation of protein acetylationsearch proteolysissearch cellular response to glyoxalsearch negative regulation of protein ubiquitinationsearch cellular response to reactive oxygen speciessearch regulation of neuron apoptotic processsearch negative regulation of protein export from nucleussearch regulation of androgen receptor signaling pathwaysearch membrane hyperpolarizationsearch negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathwaysearch negative regulation of neuron apoptotic processsearch positive regulation of protein localization to nucleussearch negative regulation of death-inducing signaling complex assemblysearch negative regulation of protein K48-linked deubiquitinationsearch positive regulation of protein homodimerization activitysearch oxidation-reduction processsearch positive regulation of tyrosine 3-monooxygenase activitysearch positive regulation of androgen receptor activitysearch inflammatory responsesearch protein stabilizationsearch negative regulation of ubiquitin-protein transferase activitysearch response to hydrogen peroxidesearch negative regulation of cell deathsearch response to stresssearch cellular response to hydrogen peroxidesearch positive regulation of pyrroline-5-carboxylate reductase activitysearch cell deathsearch adult locomotory behaviorsearch regulation of TRAIL receptor biosynthetic processsearch negative regulation of oxidative stress-induced cell deathsearch positive regulation of oxidative phosphorylation uncoupler activitysearch negative regulation of hydrogen peroxide-induced neuron deathsearch dopamine uptake involved in synaptic transmissionsearch negative regulation of apoptotic processsearch negative regulation of gene expressionsearch negative regulation of hydrogen peroxide-induced cell deathsearch negative regulation of protein sumoylationsearch positive regulation of dopamine biosynthetic processsearch negative regulation of protein kinase activitysearch negative regulation of neuron deathsearch negative regulation of protein phosphorylationsearch membrane depolarizationsearch negative regulation of TRAIL-activated apoptotic signaling pathwaysearch extracellular vesicular exosomesearch nucleussearch mitochondrionsearch cytoplasmsearch membrane raftsearch cytosolsearch PML bodysearch membranesearch plasma membranesearch mitochondrial respiratory chain complex Isearch chromatinsearch

Chain InterPro annotation
A ThiJ/PfpIsearch DJ-1search Class I glutamine amidotransferase-likesearch