3cyu Summary


Human Carbonic Anhydrase II complexed with Cryptophane biosensor and xenon

The structure was published by Aaron, J.A., Chambers, J.M., Jude, K.M., Di Costanzo, L., Dmochowski, I.J., and Christianson, D.W., in 2008 in a paper entitled "Structure of a 129Xe-cryptophane biosensor complexed with human carbonic anhydrase II." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.7 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 257 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P00918) zinc ion bindingsearch carbonate dehydratase activitysearch metal ion bindingsearch protein bindingsearch lyase activitysearch plasma membranesearch myelin sheathsearch extracellular spacesearch basolateral plasma membranesearch cytosolsearch extracellular vesicular exosomesearch cytoplasmsearch apical part of cellsearch microvillussearch membranesearch axonsearch response to estrogensearch bicarbonate transportsearch kidney developmentsearch response to organic substancesearch positive regulation of cellular pH reductionsearch positive regulation of synaptic transmission, GABAergicsearch regulation of anion transportsearch response to pHsearch response to steroid hormonesearch one-carbon metabolic processsearch positive regulation of dipeptide transmembrane transportsearch cellular response to fluid shear stresssearch positive regulation of bone resorptionsearch positive regulation of osteoclast differentiationsearch angiotensin-activated signaling pathwaysearch small molecule metabolic processsearch regulation of intracellular pHsearch response to zinc ionsearch morphogenesis of an epitheliumsearch regulation of chloride transportsearch odontogenesis of dentin-containing toothsearch secretionsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch