3cyf Summary

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Crystal Structure of E18N DJ-1

The structure was published by Witt, A.C., Lakshminarasimhan, M., Remington, B.C., Hasim, S., Pozharski, E., and Wilson, M.A., in 2008 in a paper entitled "Cysteine pKa depression by a protonated glutamic acid in human DJ-1." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.6 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Protein DJ-1. This molecule has the UniProt identifier Q99497 (PARK7_HUMAN)search. The sample contained 197 residues which is 100% of the natural sequence. Out of 197 residues 186 were observed and are deposited in the PDB.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Protein DJ-1 Q99497 (1-189) (PARK7_HUMAN)search Homo sapienssearch 99% 197 94%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q99497 (1 - 189) Protein DJ-1 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (Q99497) Rossmann foldsearch PF01965: DJ-1/PfpI familysearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (Q99497) negative regulation of protein export from nucleussearch cellular response to glyoxalsearch glyoxal catabolic processsearch positive regulation of tyrosine 3-monooxygenase activitysearch positive regulation of L-dopa decarboxylase activitysearch regulation of neuron apoptotic processsearch cellular response to oxidative stresssearch regulation of mitochondrial membrane potentialsearch negative regulation of protein ubiquitinationsearch dopamine uptake involved in synaptic transmissionsearch negative regulation of cell deathsearch negative regulation of protein K48-linked deubiquitinationsearch negative regulation of protein bindingsearch inflammatory responsesearch mitochondrion organizationsearch negative regulation of ubiquitin-specific protease activitysearch membrane hyperpolarizationsearch regulation of inflammatory responsesearch cellular response to hydrogen peroxidesearch negative regulation of death-inducing signaling complex assemblysearch negative regulation of apoptotic processsearch negative regulation of ubiquitin-protein transferase activitysearch negative regulation of protein phosphorylationsearch autophagysearch protein stabilizationsearch positive regulation of superoxide dismutase activitysearch cellular response to reactive oxygen speciessearch hydrogen peroxide metabolic processsearch negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathwaysearch negative regulation of neuron deathsearch negative regulation of hydrogen peroxide-induced cell deathsearch single fertilizationsearch positive regulation of transcription from RNA polymerase II promotersearch negative regulation of extrinsic apoptotic signaling pathwaysearch lactate biosynthetic processsearch negative regulation of gene expressionsearch positive regulation of protein homodimerization activitysearch glycolate biosynthetic processsearch regulation of TRAIL receptor biosynthetic processsearch positive regulation of dopamine biosynthetic processsearch negative regulation of hydrogen peroxide-induced neuron deathsearch response to hydrogen peroxidesearch adult locomotory behaviorsearch negative regulation of neuron apoptotic processsearch negative regulation of protein kinase activitysearch negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathwaysearch positive regulation of androgen receptor activitysearch negative regulation of oxidative stress-induced cell deathsearch response to stresssearch negative regulation of protein acetylationsearch positive regulation of L-dopa biosynthetic processsearch membrane depolarizationsearch positive regulation of pyrroline-5-carboxylate reductase activitysearch cell deathsearch negative regulation of protein sumoylationsearch oxidation-reduction processsearch synaptic transmission, dopaminergicsearch methylglyoxal catabolic process to D-lactatesearch positive regulation of mitochondrial electron transport, NADH to ubiquinonesearch positive regulation of protein localization to nucleussearch proteolysissearch regulation of androgen receptor signaling pathwaysearch positive regulation of interleukin-8 productionsearch negative regulation of TRAIL-activated apoptotic signaling pathwaysearch positive regulation of oxidative phosphorylation uncoupler activitysearch nucleussearch mitochondrionsearch extracellular vesicular exosomesearch membranesearch plasma membranesearch cytoplasmsearch membrane raftsearch PML bodysearch chromatinsearch mitochondrial respiratory chain complex Isearch cytosolsearch hydrolase activitysearch scaffold protein bindingsearch protein bindingsearch peptidase activitysearch cytokine bindingsearch single-stranded DNA bindingsearch protein homodimerization activitysearch small protein conjugating enzyme bindingsearch glyoxalase III activitysearch receptor bindingsearch repressing transcription factor bindingsearch peroxiredoxin activitysearch cuprous ion bindingsearch enzyme bindingsearch peroxidase activitysearch glyoxalase (glycolic acid-forming) activitysearch ubiquitin-specific protease bindingsearch double-stranded DNA bindingsearch core promoter bindingsearch tyrosine 3-monooxygenase activator activitysearch small protein activating enzyme bindingsearch superoxide dismutase copper chaperone activitysearch cupric ion bindingsearch mRNA bindingsearch transcription factor bindingsearch oxidoreductase activity, acting on peroxide as acceptorsearch L-dopa decarboxylase activator activitysearch androgen receptor bindingsearch identical protein bindingsearch transcription coactivator activitysearch RNA bindingsearch

Chain InterPro annotation
A ThiJ/PfpIsearch DJ-1search Class I glutamine amidotransferase-likesearch