3cy6 Summary


Crystal Structure of E18Q DJ-1

The structure was published by Witt, A.C., Lakshminarasimhan, M., Remington, B.C., Hasim, S., Pozharski, E., and Wilson, M.A., in 2008 in a paper entitled "Cysteine pKa depression by a protonated glutamic acid in human DJ-1." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.35 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Protein DJ-1. This molecule has the UniProt identifier Q99497 (PARK7_HUMAN)search. The sample contained 197 residues which is 100% of the natural sequence. Out of 197 residues 186 were observed and are deposited in the PDB.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Protein DJ-1 Q99497 (1-189) (PARK7_HUMAN)search Homo sapienssearch 99% 197 94%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q99497 (1 - 189) Protein DJ-1 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (Q99497) Rossmann foldsearch PF01965: DJ-1/PfpI familysearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (Q99497) lactate biosynthetic processsearch negative regulation of cell deathsearch negative regulation of protein acetylationsearch positive regulation of superoxide dismutase activitysearch negative regulation of apoptotic processsearch dopamine uptake involved in synaptic transmissionsearch positive regulation of protein homodimerization activitysearch negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathwaysearch negative regulation of gene expressionsearch proteolysissearch hydrogen peroxide metabolic processsearch positive regulation of oxidative phosphorylation uncoupler activitysearch regulation of neuron apoptotic processsearch positive regulation of androgen receptor activitysearch regulation of mitochondrial membrane potentialsearch negative regulation of protein bindingsearch negative regulation of oxidative stress-induced cell deathsearch cellular response to reactive oxygen speciessearch glyoxal catabolic processsearch positive regulation of mitochondrial electron transport, NADH to ubiquinonesearch cellular response to oxidative stresssearch response to stresssearch positive regulation of pyrroline-5-carboxylate reductase activitysearch negative regulation of protein ubiquitinationsearch synaptic transmission, dopaminergicsearch positive regulation of dopamine biosynthetic processsearch negative regulation of hydrogen peroxide-induced cell deathsearch cellular response to hydrogen peroxidesearch negative regulation of protein kinase activitysearch negative regulation of protein K48-linked deubiquitinationsearch single fertilizationsearch positive regulation of L-dopa biosynthetic processsearch regulation of inflammatory responsesearch methylglyoxal catabolic process to D-lactatesearch protein stabilizationsearch positive regulation of tyrosine 3-monooxygenase activitysearch response to hydrogen peroxidesearch oxidation-reduction processsearch positive regulation of transcription from RNA polymerase II promotersearch negative regulation of neuron deathsearch regulation of TRAIL receptor biosynthetic processsearch mitochondrion organizationsearch positive regulation of L-dopa decarboxylase activitysearch cell deathsearch negative regulation of hydrogen peroxide-induced neuron deathsearch negative regulation of death-inducing signaling complex assemblysearch negative regulation of ubiquitin-specific protease activitysearch autophagysearch negative regulation of protein export from nucleussearch cellular response to glyoxalsearch negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathwaysearch adult locomotory behaviorsearch negative regulation of extrinsic apoptotic signaling pathwaysearch negative regulation of protein phosphorylationsearch glycolate biosynthetic processsearch regulation of androgen receptor signaling pathwaysearch negative regulation of neuron apoptotic processsearch positive regulation of interleukin-8 productionsearch negative regulation of ubiquitin-protein transferase activitysearch negative regulation of TRAIL-activated apoptotic signaling pathwaysearch positive regulation of protein localization to nucleussearch negative regulation of protein sumoylationsearch membrane depolarizationsearch inflammatory responsesearch membrane hyperpolarizationsearch transcription coactivator activitysearch identical protein bindingsearch repressing transcription factor bindingsearch protein bindingsearch scaffold protein bindingsearch tyrosine 3-monooxygenase activator activitysearch protein homodimerization activitysearch small protein activating enzyme bindingsearch ubiquitin-specific protease bindingsearch peroxiredoxin activitysearch receptor bindingsearch double-stranded DNA bindingsearch enzyme bindingsearch RNA bindingsearch glyoxalase (glycolic acid-forming) activitysearch small protein conjugating enzyme bindingsearch peroxidase activitysearch single-stranded DNA bindingsearch peptidase activitysearch hydrolase activitysearch androgen receptor bindingsearch superoxide dismutase copper chaperone activitysearch mRNA bindingsearch transcription factor bindingsearch cuprous ion bindingsearch cytokine bindingsearch L-dopa decarboxylase activator activitysearch core promoter bindingsearch cupric ion bindingsearch oxidoreductase activity, acting on peroxide as acceptorsearch glyoxalase III activitysearch extracellular vesicular exosomesearch mitochondrionsearch PML bodysearch cytoplasmsearch nucleussearch membrane raftsearch chromatinsearch cytosolsearch plasma membranesearch membranesearch mitochondrial respiratory chain complex Isearch

Chain InterPro annotation
A ThiJ/PfpIsearch DJ-1search Class I glutamine amidotransferase-likesearch