3cxd Summary

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Crystal structure of anti-osteopontin antibody 23C3 in complex with its epitope peptide

The structure was published by Du, J., Hou, S., Zhong, C., et al., Wang, H., Guo, Y., and Ding, J., in 2008 in a paper entitled "Molecular basis of recognition of human osteopontin by 23C3, a potential therapeutic antibody for treatment of rheumatoid arthritis" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely Fab fragment of anti-osteopontin antibody 23C3, Light chain, Fab fragment of anti-osteopontin antibody 23C3, Heavy chain, and a peptide from osteopontin.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
L Fab fragment of anti-osteopontin antibody 23C3, Light chain Not available
Mus musculussearch Not available 213 100%
H Fab fragment of anti-osteopontin antibody 23C3, Heavy chain Not available
Mus musculussearch Not available 216 100%
P a peptide from osteopontin P10451 (40-51) (OSTP_HUMAN)search Homo sapienssearch < 90% 12 75%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P10451 (40 - 51) a peptide from osteopontin

Chain Structural classification (CATH) Sequence family (Pfam)
L Immunoglobulinssearch
H Immunoglobulinssearch
P Osteopontinsearch
Chain InterPro annotation
L Immunoglobulin/major histocompatibility complex, conserved sitesearch search Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch Immunoglobulin V-set domainsearch Immunoglobulin-like foldsearch
H search Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch Immunoglobulin V-set domainsearch Immunoglobulin-like foldsearch
P