› 3ctn

Solution NMR

STRUCTURE OF CALCIUM-SATURATED CARDIAC TROPONIN C, NMR, 30 STRUCTURES

Released:
DOI: 10.2210/pdb3ctn/pdb
PDB entry 3ctn coloured by chain, ensemble of 30 models, front view.
PDB entry 3ctn coloured by chain, ensemble of 30 models, side view.
PDB entry 3ctn coloured by chain, ensemble of 30 models, top view.
Source organism: Gallus gallus
Primary publication:
Structure of cardiac muscle troponin C unexpectedly reveals a closed regulatory domain.
Sia SK, Li MX, Spyracopoulos L, Gagné SM, Liu W, Putkey JA, Sykes BD
J Biol Chem 272 18216-21 (1997)
PMID: 9218458

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140775 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Troponin C, slow skeletal and cardiac muscles Chain: A
Molecule details ›
Chain: A
Length: 76 amino acids
Theoretical weight: 8.84 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli
UniProt:
  • Canonical: P09860 (Residues: 86-161; Coverage: 47%)
Gene name: TNNC1
Sequence domains: EF-hand domain pair
Structure domains: EF-hand

Ligands and Environments

1 bound ligand:
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli

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Citations

20 review citations

Regulation of contraction in striated muscle.
Gordon et al. (2000)
19 more

5 mentions without citation

Solution structure of human cardiac troponin C in complex with the green tea polyphenol, (-)-epigallocatechin 3-gallate.
Robertson et al. (2009)
4 more