Human ABL kinase in complex with nilotinib
The structure was published by Weisberg, E., Manley, P.W., Breitenstein, W., et al., Wright, R.D., Gilliland, D.G., and Griffin, J.D., in 2005 in a paper entitled "Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl" (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.21 Å and deposited in 2008.
The experimental data on which the structure is based was also deposited.
This PDB entry contains multiple copies of the structure of Proto-oncogene tyrosine-protein kinase ABL1.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: