3cs8 Summary


Structural and Biochemical Basis for the Binding Selectivity of PPARg to PGC-1a

The structure was published by Li, Y., Kovach, A., Suino-Powell, K., Martynowski, D., and Xu, H.E., in 2008 in a paper entitled "Structural and biochemical basis for the binding selectivity of peroxisome proliferator-activated receptor gamma to PGC-1alpha." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Peroxisome proliferator-activated receptor gamma and PGC-1alfa peptide.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Peroxisome proliferator-activated receptor gamma P37231 (234-504) (PPARG_HUMAN)search Homo sapienssearch < 90% 275 97%
B PGC-1alfa peptide Q9UBK2 (141-152) (PRGC1_HUMAN)search Homo sapienssearch < 90% 12 100%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P37231 (234 - 504) Peroxisome proliferator-activated receptor gamma Homo sapiens
Q9UBK2 (141 - 152) PGC-1alfa peptide

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P37231) DNA bindingsearch sequence-specific DNA binding transcription factor activitysearch steroid hormone receptor activitysearch ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activitysearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch nucleussearch

Chain InterPro annotation
A Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Peroxisome proliferator-activated receptorsearch Nuclear hormone receptor, ligand-bindingsearch