3cr5 Summary


X-ray structure of bovine Pnt-Zn(2+),Ca(2+)-S100B

The structure was published by Charpentier, T.H., Wilder, P.T., Liriano, M.A., et al., Coop, A., Toth, E.A., and Weber, D.J., in 2008 in a paper entitled "Divalent metal ion complexes of S100B in the absence and presence of pentamidine." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.85 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Protein S100-B. This molecule has the UniProt identifier P02638 (S100B_BOVIN)search. The sample contained 92 residues which is 100% of the natural sequence. Out of 92 residues 89 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
X Protein S100-B P02638 (1-92) (S100B_BOVIN)search Bos taurussearch 96% 92 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P02638 (1 - 92) Protein S100-B Bos taurus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
X (P02638) S100 proteinssearch EF-handsearch PF00036: EF handsearch, PF01023: S-100/ICaBP type calcium binding domainsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
X (P02638) cytoplasmsearch nucleussearch neuronal cell bodysearch perinuclear region of cytoplasmsearch intracellular membrane-bounded organellesearch rufflesearch calcium ion bindingsearch protein homodimerization activitysearch zinc ion bindingsearch calcium-dependent protein bindingsearch S100 protein bindingsearch protein bindingsearch RAGE receptor bindingsearch kinase inhibitor activitysearch identical protein bindingsearch metal ion bindingsearch tau protein bindingsearch regulation of neuronal synaptic plasticitysearch negative regulation of phosphorylationsearch axonogenesissearch astrocyte activationsearch memorysearch positive regulation of complement activationsearch phosphorylationsearch regulation of translationsearch learning or memorysearch positive regulation of I-kappaB kinase/NF-kappaB signalingsearch

Chain InterPro annotation
X S100/Calbindin-D9k, conserved sitesearch EF-hand domainsearch EF-hand domain pairsearch S100/CaBP-9k-type, calcium binding, subdomainsearch EF-Hand 1, calcium-binding sitesearch Protein S100-Bsearch