3cr2 Summary

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X-ray structure of bovine Zn(2+),Ca(2+)-S100B

The structure was published by Charpentier, T.H., Wilder, P.T., Liriano, M.A., et al., Coop, A., Toth, E.A., and Weber, D.J., in 2008 in a paper entitled "Divalent metal ion complexes of S100B in the absence and presence of pentamidine." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.88 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Protein S100-B. This molecule has the UniProt identifier P02638 (S100B_BOVIN)search. The sample contained 92 residues which is 100% of the natural sequence. Out of 92 residues 88 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Protein S100-B P02638 (1-92) (S100B_BOVIN)search Bos taurussearch 96% 92 97%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P02638 (1 - 92) Protein S100-B Bos taurus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P02638) S100 proteinssearch EF-handsearch PF00036: EF handsearch, PF01023: S-100/ICaBP type calcium binding domainsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P02638) calcium ion bindingsearch zinc ion bindingsearch protein homodimerization activitysearch protein bindingsearch RAGE receptor bindingsearch S100 protein bindingsearch identical protein bindingsearch kinase inhibitor activitysearch calcium-dependent protein bindingsearch metal ion bindingsearch tau protein bindingsearch cytoplasmsearch nucleussearch perinuclear region of cytoplasmsearch rufflesearch neuronal cell bodysearch positive regulation of complement activationsearch regulation of translationsearch memorysearch learning or memorysearch phosphorylationsearch astrocyte activationsearch axonogenesissearch negative regulation of phosphorylationsearch positive regulation of I-kappaB kinase/NF-kappaB signalingsearch regulation of neuronal synaptic plasticitysearch

Chain InterPro annotation
A S100/Calbindin-D9k, conserved sitesearch EF-hand domainsearch EF-hand domain pairsearch S100/CaBP-9k-type, calcium binding, subdomainsearch EF-Hand 1, calcium-binding sitesearch Protein S100-Bsearch