3cr2 Summary

pdbe.org/3cr2
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X-ray structure of bovine Zn(2+),Ca(2+)-S100B

The structure was published by Charpentier, T.H., Wilder, P.T., Liriano, M.A., et al., Coop, A., Toth, E.A., and Weber, D.J., in 2008 in a paper entitled "Divalent metal ion complexes of S100B in the absence and presence of pentamidine." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.88 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Protein S100-B. This molecule has the UniProt identifier P02638 (S100B_BOVIN)search. The sample contained 92 residues which is 100% of the natural sequence. Out of 92 residues 88 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Protein S100-B P02638 (1-92) (S100B_BOVIN)search Bos taurussearch 96% 92 97%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P02638 (1 - 92) Protein S100-B Bos taurus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P02638) S100 proteinssearch EF-handsearch PF00036: EF handsearch, PF01023: S-100/ICaBP type calcium binding domainsearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A (P02638) nucleussearch neuronal cell bodysearch cytoplasmsearch intracellular membrane-bounded organellesearch perinuclear region of cytoplasmsearch rufflesearch learning or memorysearch axonogenesissearch positive regulation of complement activationsearch regulation of neuronal synaptic plasticitysearch memorysearch negative regulation of phosphorylationsearch regulation of translationsearch positive regulation of I-kappaB kinase/NF-kappaB signalingsearch astrocyte activationsearch phosphorylationsearch RAGE receptor bindingsearch protein bindingsearch tau protein bindingsearch calcium ion bindingsearch zinc ion bindingsearch S100 protein bindingsearch protein homodimerization activitysearch calcium-dependent protein bindingsearch kinase inhibitor activitysearch metal ion bindingsearch identical protein bindingsearch

Chain InterPro annotation
A S100/Calbindin-D9k, conserved sitesearch EF-hand domainsearch EF-hand domain pairsearch S100/CaBP-9k-type, calcium binding, subdomainsearch EF-Hand 1, calcium-binding sitesearch Protein S100-Bsearch