Crystal Structure of Akt-1 complexed with substrate peptide and inhibitor
The structure was published by Lippa, B., Pan, G., Corbett, M., et al., Kakar, S., Clark, T., and Morris, J., in 2008 in a paper entitled "Synthesis and structure based optimization of novel Akt inhibitors" (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2008.
The experimental data on which the structure is based was also deposited.
This PDB entry contains a complex of 2 biomacromolecules, namely RAC-alpha serine/threonine-protein kinase and Glycogen synthase kinase-3 beta.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule most likely forms heterodimers.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 2 unique UniProt proteins: