3cqu Summary


Crystal Structure of Akt-1 complexed with substrate peptide and inhibitor

The structure was published by Lippa, B., Pan, G., Corbett, M., et al., Kakar, S., Clark, T., and Morris, J., in 2008 in a paper entitled "Synthesis and structure based optimization of novel Akt inhibitors" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely RAC-alpha serine/threonine-protein kinase and Glycogen synthase kinase-3 beta.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A RAC-alpha serine/threonine-protein kinase P31749 (144-480) (AKT1_HUMAN)search Homo sapienssearch 92% 342 93%
C Glycogen synthase kinase-3 beta P49841 (3-12) (GSK3B_HUMAN)search Homo sapienssearch 91% 10 100%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P31749 (144 - 480) RAC-alpha serine/threonine-protein kinase Homo sapiens
P49841 (3 - 12) Glycogen synthase kinase-3 beta

Chain Structural classification (CATH) Sequence family (Pfam)
A (P31749) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch, PF00433: Protein kinase C terminal domainsearch
C (P49841)

Chain ID Biological process (GO) Molecular function (GO)
A (P31749) protein phosphorylationsearch protein kinase activitysearch protein serine/threonine kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch

Chain InterPro annotation
A Protein kinase domainsearch AGC-kinase, C-terminalsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Protein kinase, C-terminalsearch