3cqe Summary

pdbe.org/3cqe
spacer

Wee1 kinase complex with inhibitor PD074291

A publication describing this structure is not available. The depositing authors are Squire, C.J.search; Baker, E.N.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Wee1-like protein kinase. This molecule has the UniProt identifier P30291 (WEE1_HUMAN)search. The sample contained 287 residues which is < 90% of the natural sequence. Out of 287 residues 251 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Wee1-like protein kinase P30291 (291-575) (WEE1_HUMAN)search Homo sapienssearch < 90% 287 89%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P30291 (291 - 575) Wee1-like protein kinase Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO)
A (P30291) protein phosphorylationsearch ATP bindingsearch protein kinase activitysearch protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch