3coq Summary


Structural Basis for Dimerization in DNA Recognition by Gal4

The structure was published by Hong, M., Fitzgerald, M.X., Harper, S., Luo, C., Speicher, D.W., and Marmorstein, R., in 2008 in a paper entitled "Structural basis for dimerization in DNA recognition by gal4." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely DNA (5'-D(*DAP*DCP*DCP*DGP*DGP*DAP*DGP*DGP*DAP*DCP*DAP*DGP*DTP*DCP*DCP*DTP*DCP*DCP*DGP*DG)-3'), DNA (5'-D(*DTP*DCP*DCP*DGP*DGP*DAP*DGP*DGP*DAP*DCP*DTP*DGP*DTP*DCP*DCP*DTP*DCP*DCP*DGP*DG)-3'), and Regulatory protein GAL4.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Regulatory protein GAL4 P04386 (8-96) (GAL4_YEAST)search Saccharomyces cerevisiae S288csearch < 90% 89 100%
B Regulatory protein GAL4 P04386 (8-96) (GAL4_YEAST)search Saccharomyces cerevisiae S288csearch < 90% 89 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P04386 (8 - 96) Regulatory protein GAL4 Saccharomyces cerevisiae

Chain Structural classification (SCOP) Sequence family (Pfam)
A, B Zn2/Cys6 DNA-binding domainsearch, Leucine zipper domainsearch Fungal Zn(2)-Cys(6) binuclear cluster domainsearch, Gal4-like dimerisation domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (P04386) regulation of transcription, DNA-templatedsearch sequence-specific DNA binding RNA polymerase II transcription factor activitysearch zinc ion bindingsearch nucleussearch

Chain InterPro annotation
A, B Zn(2)-C6 fungal-type DNA-binding domainsearch Gal4 dimerisation domainsearch