3coq Summary

pdbe.org/3coq
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Structural Basis for Dimerization in DNA Recognition by Gal4

The structure was published by Hong, M., Fitzgerald, M.X., Harper, S., Luo, C., Speicher, D.W., and Marmorstein, R., in 2008 in a paper entitled "Structural basis for dimerization in DNA recognition by gal4." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely DNA (5'-D(*DAP*DCP*DCP*DGP*DGP*DAP*DGP*DGP*DAP*DCP*DAP*DGP*DTP*DCP*DCP*DTP*DCP*DCP*DGP*DG)-3'), DNA (5'-D(*DTP*DCP*DCP*DGP*DGP*DAP*DGP*DGP*DAP*DCP*DTP*DGP*DTP*DCP*DCP*DTP*DCP*DCP*DGP*DG)-3'), and Regulatory protein GAL4.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Regulatory protein GAL4 P04386 (8-96) (GAL4_YEAST)search Saccharomyces cerevisiae S288csearch < 90% 89 100%
B Regulatory protein GAL4 P04386 (8-96) (GAL4_YEAST)search Saccharomyces cerevisiae S288csearch < 90% 89 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P04386 (8 - 96) Regulatory protein GAL4 Saccharomyces cerevisiae

Chain Structural classification (SCOP) Sequence family (Pfam)
A, B Zn2/Cys6 DNA-binding domainsearch, Leucine zipper domainsearch Fungal Zn(2)-Cys(6) binuclear cluster domainsearch, Gal4-like dimerisation domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (P04386) regulation of transcription, DNA-templatedsearch sequence-specific DNA binding RNA polymerase II transcription factor activitysearch zinc ion bindingsearch nucleussearch

Chain InterPro annotation
A, B Zn(2)-C6 fungal-type DNA-binding domainsearch Gal4 dimerisation domainsearch