3coi Summary


Crystal structure of p38delta kinase

A publication describing this structure is not available. The depositing authors are Atwell, S.search; Burley, S.K.search; Houle, A.search; Ramos, A.search; Sauder, J.M.search; New York SGX Research Center for Structural Genomics (NYSGXRC)search

This crystal structure was determined using X-ray diffraction at a resolution of 2.09 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 13. This molecule has the UniProt identifier O15264 (MK13_HUMAN)search. The sample contained 353 residues which is 96% of the natural sequence. Out of 353 residues 338 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 13 O15264 (2-352) (MK13_HUMAN)search Homo sapienssearch 96% 353 97%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O15264 (2 - 352) Mitogen-activated protein kinase 13 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (O15264) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (O15264) MAP kinase activitysearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein bindingsearch ATP bindingsearch protein serine/threonine kinase activitysearch kinase activitysearch transferase activitysearch nucleotide bindingsearch protein phosphorylationsearch cell cyclesearch MAPK cascadesearch intracellular signal transductionsearch peptidyl-serine phosphorylationsearch phosphorylationsearch neurotrophin TRK receptor signaling pathwaysearch Ras protein signal transductionsearch transcription, DNA-templatedsearch positive regulation of interleukin-6 productionsearch positive regulation of inflammatory responsesearch regulation of transcription, DNA-templatedsearch response to stresssearch response to osmotic stresssearch cytosolsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch