Crystal structure of Aurora-A in complex with a pentacyclic inhibitor
The structure was published by Rawson, T.E., Ruth, M., Blackwood, E., et al., Zhu, B.Y., Ruger, P., and Cochran, A.G., in 2008 in a paper entitled "A pentacyclic aurora kinase inhibitor (AKI-001) with high in vivo potency and oral bioavailability." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.7 Å and deposited in 2008.
The experimental data on which the structure is based was also deposited.
This PDB entry contains multiple copies of the structure of Serine/threonine-protein kinase 6.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: