3coh Summary

pdbe.org/3coh
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Crystal structure of Aurora-A in complex with a pentacyclic inhibitor

The structure was published by Rawson, T.E., Ruth, M., Blackwood, E., et al., Zhu, B.Y., Ruger, P., and Cochran, A.G., in 2008 in a paper entitled "A pentacyclic aurora kinase inhibitor (AKI-001) with high in vivo potency and oral bioavailability." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.7 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Serine/threonine-protein kinase 6.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Serine/threonine-protein kinase 6 O14965 (124-391) (AURKA_HUMAN)search Homo sapienssearch < 90% 268 92%
B Serine/threonine-protein kinase 6 O14965 (124-391) (AURKA_HUMAN)search Homo sapienssearch < 90% 268 92%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O14965 (124 - 391) Serine/threonine-protein kinase 6 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (O14965) protein serine/threonine kinase activitysearch protein kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch