3cld Summary


Ligand binding domain of the glucocorticoid receptor complexed with fluticazone furoate

The structure was published by Biggadike, K., Bledsoe, R.K., Hassell, A.M., et al., McLay, I.M., Shewchuk, L.M., and Stewart, E.L., in 2008 in a paper entitled "X-ray crystal structure of the novel enhanced-affinity glucocorticoid agonist fluticasone furoate in the glucocorticoid receptor-ligand binding domain." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.84 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Glucocorticoid receptor and Tif2 coactivator motif.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glucocorticoid receptor P04150 (521-777) (GCR_HUMAN)search Homo sapienssearch < 90% 259 93%
B Glucocorticoid receptor P04150 (521-777) (GCR_HUMAN)search Homo sapienssearch < 90% 259 93%
H Tif2 coactivator motif Q15596 (740-751) (NCOA2_HUMAN)search Homo sapienssearch < 90% 12 75%
C Tif2 coactivator motif Q15596 (740-751) (NCOA2_HUMAN)search Homo sapienssearch < 90% 12 75%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P04150 (521 - 777) Glucocorticoid receptor Homo sapiens
Q15596 (740 - 751) Tif2 coactivator motif

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch
H, C

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (P04150) steroid hormone receptor activitysearch sequence-specific DNA binding transcription factor activitysearch DNA bindingsearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch nucleussearch

Chain InterPro annotation
A, B Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch
H, C