3cl3 Summary

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Crystal Structure of a vFLIP-IKKgamma complex: Insights into viral activation of the IKK signalosome

The structure was published by Bagneris, C., Ageichik, A.V., Cronin, N., et al., Boshoff, C., Waksman, G., and Barrett, T., in 2008 in a paper entitled "Crystal structure of a vFlip-IKKgamma complex: insights into viral activation of the IKK signalosome." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.2 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely ORF K13 and NF-kappa-B essential modulator.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A ORF K13 Q76RF1 (1-178) (Q76RF1_HHV8)search Human herpesvirus 8search 95% 183 93%
B ORF K13 Q76RF1 (1-178) (Q76RF1_HHV8)search Human herpesvirus 8search 95% 183 93%
D NF-kappa-B essential modulator Q9Y6K9 (150-252) (NEMO_HUMAN)search Homo sapienssearch < 90% 130 45%
E NF-kappa-B essential modulator Q9Y6K9 (150-272) (NEMO_HUMAN)search Homo sapienssearch < 90% 130 45%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q76RF1 (1 - 178) ORF K13 Human herpesvirus 8
Q9Y6K9 (150 - 252) NF-kappa-B essential modulator Homo sapiens

Chain Sequence family (Pfam)
A, B Death effector domainsearch
D, E

Chain ID Biological process (GO)
A, B (Q76RF1) regulation of apoptotic processsearch

Chain InterPro annotation
A, B Death effector domainsearch Death-like domainsearch
D, E