Structure analysis

Crystal Structure of a vFLIP-IKKgamma complex: Insights into viral activation of the IKK signalosome

X-ray diffraction
3.2Å resolution
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero tetramer
Accessible surface area: 24560.42 Å2
Buried surface area: 5423.11 Å2
Dissociation area: 778.5 Å2
Dissociation energy (ΔGdiss): 1.43 kcal/mol
Dissociation entropy (TΔSdiss): 12.37 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-181192

Macromolecules

Chains: A, B
Length: 183 amino acids
Theoretical weight: 20.67 KDa
Source organism: Human gammaherpesvirus 8
Expression system: Escherichia coli
UniProt:
  • Canonical: Q76RF1 (Residues: 1-178; Coverage: 95%)
Gene names: HHV8GK18_gp80, ORF71
Pfam: Death effector domain
InterPro:
CATH: Death Domain, Fas

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Chains: D, E
Length: 130 amino acids
Theoretical weight: 14.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y6K9 (Residues: 150-272; Coverage: 29%)
Gene names: FIP3, IKBKG, NEMO
CATH: L1 transposable element, trimerization domain

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