3ciu Summary

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Site-Selective Glycosylation of Cysteine-93 beta on the Surface of Bovine Hemoglobin and its Application as a Novel Oxygen Therapeutic

A publication describing this structure is not available. The depositing authors are Bhatt, V.S.search; Zhang, Y.search; Sun, G.search; Wang, P.G.search; Palmer, A.F.search

This crystal structure was determined using X-ray diffraction at a resolution of 3.5 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin subunit alpha and Hemoglobin subunit beta.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin subunit alpha P01966 (2-142) (HBA_BOVIN)search Bos taurussearch 99% 141 100%
C Hemoglobin subunit alpha P01966 (2-142) (HBA_BOVIN)search Bos taurussearch 99% 141 100%
B Hemoglobin subunit beta P02070 (1-145) (HBB_BOVIN)search Bos taurussearch 100% 145 100%
D Hemoglobin subunit beta P02070 (1-145) (HBB_BOVIN)search Bos taurussearch 100% 145 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P01966 (2 - 142) Hemoglobin subunit alpha Bos taurus
P02070 (1 - 145) Hemoglobin subunit beta Bos taurus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P01966) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P02070) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, C (P01966) oxygen bindingsearch iron ion bindingsearch heme bindingsearch metal ion bindingsearch oxygen transporter activitysearch protein bindingsearch oxygen transportsearch transportsearch hemoglobin complexsearch
B, D (P02070) heme bindingsearch oxygen bindingsearch iron ion bindingsearch metal ion bindingsearch oxygen transporter activitysearch oxygen transportsearch transportsearch hemoglobin complexsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch