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EBI PDBe PDBeView

PDBe Entry: 3cho view

Crystal structure of leukotriene a4 hydrolase in complex with 2-amino-N-[4-(phenylmethoxy)phenyl]-acetamide
Summary
Header HYDROLASEsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 1.8 Å, R-factor: 18.9%, Free R-factor: 22.3%, Spacegroup: P 21 21 21
Released 22/04/2008, deposition: 10/03/2008, last revision: 24/02/2009
Authors Thunnissen, M.M.G.M.search; Adler, M.search; Whitlow, M.search
Primary citation Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase.
BIOORG.MED.CHEM.search vol:16, pag:4963-4983 (2008) [PubMed ID 18394906 ]search
Keywords EPOXIDE HYDROLASEsearch, ALPHA-BETA PROTEINsearch, LEUKOTRIENE BIOSYNTHESISsearch, METALLOPROTEASEsearch, Inhibitor complexsearch, Alternative splicingsearch, Cytoplasmsearch, Metal-bindingsearch, Multifunctional enzymesearch, Zincsearch
EC 3.3.2.6 ExPASy BRENDA search (A)
Organism Homo sapiens(human) 9606search(A)
UniProt Leukotriene A-4 hydrolase (EC 3.3.2.6) (Leukotriene A(4) hydrolase) (LTA-4 hydrolase) P09960search (A)
Solvent A
Related entries 1hs6, 1gw6, 1h19, 1sqm, 3chp, 3chq, 3chr, 3chs, 2vj8
Polymers
Id Name Type UniProt Residues Observed
A Leukotriene A-4 hydrolase Protein P09960 (LKHA4_HUMAN)search
 610 100%
Heterogens
Id Name Ligands
A ZINC ION ZN search
A YTTERBIUM (III) ION YB search
A ACETATE ION ACT search
A N-[4-(BENZYLOXY)PHENYL]GLYCINAMIDE 4BG search
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