› 3ch2

X-ray diffraction
1.8Å resolution

Crystal Structure Analysis of SERA5E from plasmodium falciparum

Released:
DOI: 10.2210/pdb3ch2/pdb
PDB entry 3ch2 coloured by chain, front view.
PDB entry 3ch2 coloured by chain, side view.
PDB entry 3ch2 coloured by chain, top view.
Source organism: Plasmodium falciparum 3D7
Primary publication:
Structural insights into the protease-like antigen Plasmodium falciparum SERA5 and its noncanonical active-site serine.
Hodder AN, Malby RL, Clarke OB, Fairlie WD, Colman PM, Crabb BS, Smith BJ
J Mol Biol 392 154-65 (2009)
PMID: 19591843

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193587 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
p50 Chain: X
Molecule details ›
Chain: X
Length: 265 amino acids
Theoretical weight: 30.66 KDa
Source organism: Plasmodium falciparum 3D7
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9TY95 (Residues: 564-828; Coverage: 27%)
Gene names: PFB0340c, SERA5
Sequence domains: Papain family cysteine protease
Structure domains: Cysteine proteinases

Ligands and Environments

1 bound ligand:
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: R3
Unit cell:
a: 103.59Å b: 103.59Å c: 72.132Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.168 0.166 0.198
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

5 review citations

Proteases as regulators of pathogenesis: examples from the Apicomplexa.
Li et al. (2012)
4 more

2 mentions without citation

Structure of the Plasmodium falciparum PfSERA5 pseudo-zymogen.
Smith et al. (2020)
1 more