IRAK-4 Inhibitors (Part II)- A structure based assessment of imidazo[1,2 a]pyridine binding
The structure was published by Buckley, G.M., Ceska, T.A., Fraser, J.L., et al., Rausch, O., Richard, M.D., and Sabin, V., in 2008 in a paper entitled "IRAK-4 inhibitors. Part II: A structure-based assessment of imidazo[1,2-a]pyridine binding" (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 3.0 Å and deposited in 2008.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of Mitogen-activated protein kinase 10. This molecule has the UniProt identifier P53779 (MK10_HUMAN). The sample contained 365 residues which is < 90% of the natural sequence. Out of 365 residues 332 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: