› 3cga

X-ray diffraction
2.03Å resolution

Crystal structure of metastasis-associated protein S100A4 in the active, calcium-bound form

Released:
DOI: 10.2210/pdb3cga/pdb
PDB entry 3cga coloured by chain, front view.
PDB entry 3cga coloured by chain, side view.
PDB entry 3cga coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of metastasis-associated protein S100A4 in the active calcium-bound form.
Pathuri P, Vogeley L, Luecke H
J Mol Biol 383 62-77 (2008)
PMID: 18783790

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150750 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein S100-A4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 101 amino acids
Theoretical weight: 11.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P26447 (Residues: 1-101; Coverage: 100%)
Gene names: CAPL, MTS1, S100A4
Sequence domains: S-100/ICaBP type calcium binding domain
Structure domains: EF-hand

Ligands and Environments

1 bound ligand:
Ligand CA 4 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-1
Spacegroup: P65
Unit cell:
a: 47.107Å b: 47.107Å c: 176.2Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.255 not available 0.331
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Binding of S100 proteins to RAGE: an update.
Leclerc et al. (2009)
3 more

10 mentions without citation

Comparison of a preQ1 riboswitch aptamer in metabolite-bound and free states with implications for gene regulation.
Jenkins et al. (2011)
9 more