3cd3 Summary


Crystal structure of phosphorylated human feline sarcoma viral oncogene homologue (v-FES) in complex with staurosporine and a consensus peptide

The structure was published by Filippakopoulos, P., Kofler, M., Hantschel, O., et al., Superti-Furga, G., Pawson, T., and Knapp, S., in 2008 in a paper entitled "Structural Coupling of SH2-Kinase Domains Links Fes and Abl Substrate Recognition and Kinase Activation" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.98 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Proto-oncogene tyrosine-protein kinase Fes/Fps and Synthetic peptide.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Proto-oncogene tyrosine-protein kinase Fes/Fps P07332 (448-822) (FES_HUMAN)search Homo sapienssearch < 90% 377 93%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P07332 (448 - 822) Proto-oncogene tyrosine-protein kinase Fes/Fps Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A SHC Adaptor Proteinsearch, Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search SH2 domainsearch, Protein tyrosine kinasesearch

Chain ID Biological process (GO) Molecular function (GO)
A (P07332) protein phosphorylationsearch transferase activity, transferring phosphorus-containing groupssearch ATP bindingsearch protein kinase activitysearch protein tyrosine kinase activitysearch

Chain InterPro annotation
A Protein kinase domainsearch SH2 domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch