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Crystal structure of phosphorylated human feline sarcoma viral oncogene homologue (v-FES) in complex with staurosporine and a consensus peptide

X-ray diffraction
1.98Å resolution
PDB entry 3cd3 coloured by chain, front view.
PDB entry 3cd3 coloured by chain, side view.
PDB entry 3cd3 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Tyrosine-protein kinase Fes/Fps and peptide
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Multimeric state: hetero dimer
Accessible surface area: 17691.02 Å2
Buried surface area: 3135.87 Å2
Dissociation area: 498.22 Å2
Dissociation energy (ΔGdiss): 5.32 kcal/mol
Dissociation entropy (TΔSdiss): 6.11 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-139509

Macromolecules

Tyrosine-protein kinase Fes/Fps
Chain: A
Length: 377 amino acids
Theoretical weight: 42.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P07332 (Residues: 448-822; Coverage: 46%)
Gene names: FES, FPS
Pfam:
InterPro:
CATH:
Tyrosine-protein kinase Fes/Fps in PDB entry 3cd3, assembly 1, front view.
Tyrosine-protein kinase Fes/Fps in PDB entry 3cd3, assembly 1, side view.
Tyrosine-protein kinase Fes/Fps in PDB entry 3cd3, assembly 1, top view.
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Synthetic peptide
Chain: B
Length: 6 amino acids
Theoretical weight: 650 Da
Source organism: Homo sapiens
Expression system: Not provided
Synthetic peptide in PDB entry 3cd3, assembly 1, front view.
Synthetic peptide in PDB entry 3cd3, assembly 1, side view.
Synthetic peptide in PDB entry 3cd3, assembly 1, top view.
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