3cc6 Summary


Crystal structure of kinase domain of protein tyrosine kinase 2 beta (PTK2B)

A publication describing this structure is not available. The depositing authors are Busam, R.D.search; Lehtio, L.search; Karlberg, T.search; Arrowsmith, C.H.search; Bountra, C.search; Collins, R.search; Dahlgren, L.G.search; Edwards, A.M.search; Flodin, S.search; Flores, A.search; Graslund, S.search; Hammarstrom, M.search; Helleday, T.search; Herman, M.D.search; Johansson, A.search; Johansson, I.search; Kallas, A.search; Kotenyova, T.search; Moche, M.search; Nilsson, M.E.search; Nordlund, P.search; Nyman, T.search; Persson, C.search; Sagemark, J.search; Svensson, L.search; Thorsell, A.G.search; Tresaugues, L.search; Van den Berg, S.search; Weigelt, J.search; Welin, M.search; Berglund, H.search; Structural Genomics Consortium (SGC)search

This crystal structure was determined using X-ray diffraction at a resolution of 1.6 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Protein tyrosine kinase 2 beta. This molecule has the UniProt identifier Q14289 (FAK2_HUMAN)search. The sample contained 281 residues which is < 90% of the natural sequence. Out of 281 residues 269 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Protein tyrosine kinase 2 beta Q14289 (414-692) (FAK2_HUMAN)search Homo sapienssearch < 90% 281 95%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q14289 (414 - 692) Protein tyrosine kinase 2 beta Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Biological process (GO) Molecular function (GO)
A (Q14289) protein phosphorylationsearch protein kinase activitysearch ATP bindingsearch protein tyrosine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch

Chain InterPro annotation
A Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch