› 3cbz

X-ray diffraction
1.38Å resolution

The Dvl2 PDZ Domain in Complex with the N2 Inhibitory Peptide

Released:
DOI: 10.2210/pdb3cbz/pdb
PDB entry 3cbz coloured by chain, front view.
PDB entry 3cbz coloured by chain, side view.
PDB entry 3cbz coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Inhibition of Wnt signaling by Dishevelled PDZ peptides.
Zhang Y, Appleton BA, Wiesmann C, Lau T, Costa M, Hannoush RN, Sidhu SS
Nat Chem Biol 5 217-9 (2009)
PMID: 19252499

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127031 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Segment polarity protein dishevelled homolog DVL-2 Chain: A
Molecule details ›
Chain: A
Length: 108 amino acids
Theoretical weight: 11.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O14641 (Residues: 264-354; Coverage: 12%)
Gene name: DVL2
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain

Ligands and Environments

2 bound ligands:
Ligand PO4 1 x PO4
Ligand EDO 2 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P212121
Unit cell:
a: 42.675Å b: 43.554Å c: 54.86Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.139 0.137 0.166
Expression system: Escherichia coli

Quick links

Citations

34 review citations

Wnt/beta-catenin signaling: components, mechanisms, and diseases.
MacDonald et al. (2009)
33 more

4 mentions without citation

The structural biology of canonical Wnt signalling.
Agostino et al. (2020)
3 more