3cbx Summary


The Dvl2 PDZ Domain in Complex with the C1 Inhibitory Peptide

The structure was published by Zhang, Y., Appleton, B.A., Wiesmann, C., et al., Costa, M., Hannoush, R.N., and Sidhu, S.S., in 2009 in a paper entitled "Inhibition of Wnt signaling by Dishevelled PDZ peptides" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.7 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Dishevelled-2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Dishevelled-2 O14641 (264-354) (DVL2_HUMAN)search Homo sapienssearch < 90% 105 100%
B Dishevelled-2 O14641 (264-354) (DVL2_HUMAN)search Homo sapienssearch < 90% 105 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O14641 (264 - 354) Dishevelled-2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Pdz3 Domainsearch PDZ domain (Also known as DHR or GLGF)search

Chain ID Biological process (GO)
A, B (O14641) Wnt signaling pathwaysearch

Chain InterPro annotation
A, B PDZ domainsearch Dishevelled-2search Dishevelled-related proteinsearch