3cbj Summary

pdbe.org/3cbj
spacer

Chagasin-Cathepsin B complex

The structure was published by Redzynia, I., Ljunggren, A., Abrahamson, M., et al., Krupa, J.C., Jaskolski, M., and Bujacz, G., in 2008 in a paper entitled "Displacement of the occluding loop by the parasite protein, chagasin, results in efficient inhibition of human cathepsin B." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Cathepsin B and Chagasin.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Cathepsin B P07858 (74-339) (CATB_HUMAN)search Homo sapienssearch < 90% 266 96%
B Chagasin Q966X9 (1-110) (CHAG_TRYCR)search Trypanosoma cruzisearch 99% 110 99%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P07858 (74 - 339) Cathepsin B Homo sapiens
Q966X9 (1 - 110) Chagasin Trypanosoma cruzi

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Cysteine proteinasessearch Papain family cysteine proteasesearch
B (Q966X9) ICP-likesearch PF09394: Chagasin family peptidase inhibitor I42search

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P07858) cysteine-type peptidase activitysearch proteolysissearch
B (Q966X9) peptidase inhibitor activitysearch cysteine-type endopeptidase inhibitor activitysearch negative regulation of endopeptidase activitysearch negative regulation of peptidase activitysearch cytoplasmic membrane-bounded vesiclesearch cytoplasmic vesiclesearch cell surfacesearch ciliary pocketsearch

Chain InterPro annotation
A Peptidase C1A, papain C-terminalsearch Peptidase C1Asearch Peptidase C1A, cathepsin Bsearch Cysteine peptidase, histidine active sitesearch Cysteine peptidase, asparagine active sitesearch
B Proteinase inhibitor I42, chagasinsearch