3cbb Summary


Crystal Structure of Hepatocyte Nuclear Factor 4alpha in complex with DNA: Diabetes Gene Product

The structure was published by Lu, P., Rha, G.B., Melikishvili, M., et al., Adkins, B.C., Fried, M.G., and Chi, Y.I., in 2008 in a paper entitled "Structural basis of natural promoter recognition by a unique nuclear receptor, HNF4alpha. Diabetes gene product." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely Hepatocyte Nuclear Factor 4-alpha promoter element DNA and Hepatocyte Nuclear Factor 4-alpha, DNA binding domain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hepatocyte Nuclear Factor 4-alpha, DNA binding domain P41235 (58-135) (HNF4A_HUMAN)search Homo sapienssearch < 90% 78 100%
B Hepatocyte Nuclear Factor 4-alpha, DNA binding domain P41235 (58-135) (HNF4A_HUMAN)search Homo sapienssearch < 90% 78 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P41235 (58 - 135) Hepatocyte Nuclear Factor 4-alpha, DNA binding domain Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Erythroid Transcription Factor GATA-1, subunit Asearch Zinc finger, C4 type (two domains)search

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (P41235) regulation of transcription, DNA-templatedsearch zinc ion bindingsearch sequence-specific DNA binding transcription factor activitysearch sequence-specific DNA bindingsearch nucleussearch

Chain InterPro annotation
A, B Zinc finger, nuclear hormone receptor-typesearch Zinc finger, NHR/GATA-typesearch