3ca2 Summary

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CRYSTALLOGRAPHIC STUDIES OF INHIBITOR BINDING SITES IN HUMAN CARBONIC ANHYDRASE II. A PENTACOORDINATED BINDING OF THE SCN-ION TO THE ZINC AT HIGH P*H

The structure was published by Eriksson, A.E., Kylsten, P.M., Jones, T.A., and Liljas, A., in 1988 in a paper entitled "Crystallographic studies of inhibitor binding sites in human carbonic anhydrase II: a pentacoordinated binding of the SCN- ion to the zinc at high pH." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 1989.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of CARBONIC ANHYDRASE II. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 259 residues which is 100% of the natural sequence. Out of 259 residues 256 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CARBONIC ANHYDRASE II P00918 (2-260) (CAH2_HUMAN)search Homo sapienssearch 98% 259 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (2 - 260) CARBONIC ANHYDRASE II Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P00918) lyase activitysearch metal ion bindingsearch carbonate dehydratase activitysearch zinc ion bindingsearch protein bindingsearch plasma membranesearch cytosolsearch cytoplasmsearch apical part of cellsearch basolateral plasma membranesearch microvillussearch membranesearch extracellular vesicular exosomesearch axonsearch extracellular spacesearch myelin sheathsearch regulation of anion transportsearch regulation of intracellular pHsearch bicarbonate transportsearch morphogenesis of an epitheliumsearch angiotensin-activated signaling pathwaysearch positive regulation of osteoclast differentiationsearch response to steroid hormonesearch response to zinc ionsearch response to estrogensearch small molecule metabolic processsearch response to organic substancesearch positive regulation of dipeptide transmembrane transportsearch positive regulation of cellular pH reductionsearch response to pHsearch positive regulation of synaptic transmission, GABAergicsearch regulation of chloride transportsearch one-carbon metabolic processsearch odontogenesis of dentin-containing toothsearch kidney developmentsearch positive regulation of bone resorptionsearch secretionsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch