3c9w Summary


Crystal Structure of ERK-2 with hypothemycin covalently bound

The structure was published by Rastelli, G., Rosenfeld, R., Reid, R., and Santi, D.V., in 2008 in a paper entitled "Molecular modeling and crystal structure of ERK2-hypothemycin complexes" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Mitogen-activated protein kinase 1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 1 P63086 (2-358) (MK01_RAT)search Rattus norvegicussearch 99% 357 94%
B Mitogen-activated protein kinase 1 P63086 (2-358) (MK01_RAT)search Rattus norvegicussearch 99% 357 94%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P63086 (2 - 358) Mitogen-activated protein kinase 1 Rattus norvegicus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P63086) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (P63086) MAP kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch ATP bindingsearch protein serine/threonine kinase activitysearch protein kinase activitysearch protein bindingsearch kinase activitysearch RNA polymerase II carboxy-terminal domain kinase activitysearch phosphatase bindingsearch phosphotyrosine bindingsearch transferase activitysearch nucleotide bindingsearch transcription factor bindingsearch mitogen-activated protein kinase kinase kinase bindingsearch protein kinase bindingsearch protein phosphorylationsearch regulation of early endosome to late endosome transportsearch T cell receptor signaling pathwaysearch mammary gland epithelial cell proliferationsearch response to epidermal growth factorsearch peptidyl-threonine phosphorylationsearch phosphorylationsearch negative regulation of cell differentiationsearch cellular response to DNA damage stimulussearch MAPK cascadesearch response to lipopolysaccharidesearch regulation of protein stabilitysearch peptidyl-serine phosphorylationsearch ERBB signaling pathwaysearch positive regulation of translationsearch cytosine metabolic processsearch response to toxic substancesearch cell cyclesearch regulation of cytoskeleton organizationsearch intracellular signal transductionsearch apoptotic processsearch labyrinthine layer blood vessel developmentsearch positive regulation of cell proliferationsearch positive regulation of transcription, DNA-templatedsearch positive regulation of peptidyl-threonine phosphorylationsearch MAPK import into nucleussearch response to estrogensearch B cell receptor signaling pathwaysearch lipopolysaccharide-mediated signaling pathwaysearch response to exogenous dsRNAsearch ERK1 and ERK2 cascadesearch sensory perception of painsearch regulation of stress-activated MAPK cascadesearch signal transductionsearch positive regulation of cell migrationsearch caveolin-mediated endocytosissearch organ morphogenesissearch regulation of Golgi inheritancesearch cellular response to organic substancesearch nucleoplasmsearch axonsearch late endosomesearch microtubule cytoskeletonsearch early endosomesearch nucleussearch mitotic spindlesearch cytoplasmsearch pseudopodiumsearch perikaryonsearch mitochondrionsearch cytosolsearch Golgi apparatussearch spindlesearch cytoskeletonsearch focal adhesionsearch microtubule organizing centersearch protein complexsearch caveolasearch dendrite cytoplasmsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Serine/threonine-protein kinase, active sitesearch Mitogen-activated protein (MAP) kinase, ERK1/2search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch