3c9w Summary


Crystal Structure of ERK-2 with hypothemycin covalently bound

The structure was published by Rastelli, G., Rosenfeld, R., Reid, R., and Santi, D.V., in 2008 in a paper entitled "Molecular modeling and crystal structure of ERK2-hypothemycin complexes" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Mitogen-activated protein kinase 1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 1 P63086 (2-358) (MK01_RAT)search Rattus norvegicussearch 99% 357 94%
B Mitogen-activated protein kinase 1 P63086 (2-358) (MK01_RAT)search Rattus norvegicussearch 99% 357 94%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P63086 (2 - 358) Mitogen-activated protein kinase 1 Rattus norvegicus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P63086) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A, B (P63086) caveolasearch dendrite cytoplasmsearch nucleussearch cytoplasmsearch protein complexsearch nucleoplasmsearch cytoskeletonsearch late endosomesearch pseudopodiumsearch early endosomesearch axonsearch mitotic spindlesearch spindlesearch Golgi apparatussearch cytosolsearch mitochondrionsearch microtubule cytoskeletonsearch microtubule organizing centersearch perikaryonsearch extracellular vesicular exosomesearch focal adhesionsearch peptidyl-serine phosphorylationsearch regulation of Golgi inheritancesearch peptidyl-threonine phosphorylationsearch signal transductionsearch regulation of stress-activated MAPK cascadesearch caveolin-mediated endocytosissearch ERBB signaling pathwaysearch cytosine metabolic processsearch organ morphogenesissearch positive regulation of cell migrationsearch response to lipopolysaccharidesearch sensory perception of painsearch protein phosphorylationsearch response to epidermal growth factorsearch apoptotic processsearch regulation of protein stabilitysearch cellular response to granulocyte macrophage colony-stimulating factor stimulussearch regulation of early endosome to late endosome transportsearch B cell receptor signaling pathwaysearch cellular response to DNA damage stimulussearch MAPK cascadesearch negative regulation of cell differentiationsearch intracellular signal transductionsearch cell cyclesearch regulation of cytoskeleton organizationsearch labyrinthine layer blood vessel developmentsearch response to toxic substancesearch mammary gland epithelial cell proliferationsearch response to exogenous dsRNAsearch positive regulation of translationsearch phosphorylationsearch T cell receptor signaling pathwaysearch MAPK import into nucleussearch lipopolysaccharide-mediated signaling pathwaysearch response to estrogensearch ERK1 and ERK2 cascadesearch positive regulation of peptidyl-threonine phosphorylationsearch positive regulation of transcription, DNA-templatedsearch positive regulation of cell proliferationsearch cellular response to organic substancesearch transferase activitysearch protein bindingsearch MAP kinase activitysearch protein serine/threonine kinase activitysearch mitogen-activated protein kinase kinase kinase bindingsearch ATP bindingsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch RNA polymerase II carboxy-terminal domain kinase activitysearch nucleotide bindingsearch phosphotyrosine bindingsearch kinase activitysearch phosphatase bindingsearch transcription factor bindingsearch protein kinase bindingsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Serine/threonine-protein kinase, active sitesearch Mitogen-activated protein (MAP) kinase, ERK1/2search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch