› 3c7q

X-ray diffraction
2.1Å resolution

Structure of VEGFR2 kinase domain in complex with BIBF1120

Released:
DOI: 10.2210/pdb3c7q/pdb
PDB entry 3c7q coloured by chain, front view.
PDB entry 3c7q coloured by chain, side view.
PDB entry 3c7q coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy.
Hilberg F, Roth GJ, Krssak M, Kautschitsch S, Sommergruber W, Tontsch-Grunt U, Garin-Chesa P, Bader G, Zoephel A, Quant J, Heckel A, Rettig WJ
Cancer Res 68 4774-82 (2008)
PMID: 18559524

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153084 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Vascular endothelial growth factor receptor 2 Chain: A
Molecule details ›
Chain: A
Length: 316 amino acids
Theoretical weight: 36.56 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P35968 (Residues: 806-1171; Coverage: 24%)
Gene names: FLK1, KDR, VEGFR2
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand SO4 5 x SO4
Ligand XIN 1 x XIN
2 modified residues:
Ligand CME 3 x CME
Ligand PTR 2 x PTR

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P212121
Unit cell:
a: 38.25Å b: 94.44Å c: 96.22Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.221 0.217 0.279
Expression system: Spodoptera frugiperda

Quick links

Citations

261 review citations

Fibroblast growth factor signalling: from development to cancer.
Turner et al. (2010)
260 more

13 mentions without citation

The Interactions of Nintedanib and Oral Anticoagulants-Molecular Mechanisms and Clinical Implications.
GrzeĊ›k et al. (2020)
12 more