3c7i Summary


PDB entry 3c7i (supersedes 2huy)

X-RAY crystal structure of the complex between the grb2-sh2 domain and a flexible ligand, FPTVN.

The structure was published by Benfield, A.P., Teresk, M.G., Plake, H.R., Delorbe, J.E., Millspaugh, L.E., and Martin, S.F., in 2006 in a paper entitled "Ligand Preorganization May be Accompanied by Entropic Penalties in Protein-Ligand Interactions." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.7 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Growth factor receptor-bound protein 2. This molecule has the UniProt identifier P62993 (GRB2_HUMAN)search. The sample contained 116 residues which is < 90% of the natural sequence. Out of 116 residues 101 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Growth factor receptor-bound protein 2 P62993 (53-162) (GRB2_HUMAN)search Homo sapienssearch 100% 116 87%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P62993 (53 - 162) Growth factor receptor-bound protein 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P62993) SH2 domainsearch SHC Adaptor Proteinsearch PF00017: SH2 domainsearch, PF00018: SH3 domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P62993) SH3/SH2 adaptor activitysearch Ras protein signal transductionsearch membranesearch

Chain InterPro annotation
A SH2 domainsearch Growth factor receptor-bound protein 2search