3c5u Summary


P38 ALPHA map kinase complexed with a benzothiazole based inhibitor

The structure was published by Liu, C., Lin, J., Pitt, S., et al., Barrish, J.C., Schieven, G.L., and Leftheris, K., in 2008 in a paper entitled "Benzothiazole based inhibitors of p38alpha MAP kinase." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 366 residues which is 100% of the natural sequence. Out of 366 residues 338 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 Q16539 (2-360) (MK14_HUMAN)search Homo sapienssearch 97% 366 92%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (2 - 360) Mitogen-activated protein kinase 14 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (Q16539) ATP bindingsearch MAP kinase activitysearch protein kinase activitysearch protein bindingsearch protein serine/threonine kinase activitysearch nucleotide bindingsearch kinase activitysearch MAP kinase kinase activitysearch NFAT protein bindingsearch transferase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch positive regulation of erythrocyte differentiationsearch toll-like receptor 3 signaling pathwaysearch 3'-UTR-mediated mRNA stabilizationsearch MyD88-dependent toll-like receptor signaling pathwaysearch peptidyl-serine phosphorylationsearch positive regulation of reactive oxygen species metabolic processsearch chemotaxissearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch transcription, DNA-templatedsearch toll-like receptor signaling pathwaysearch signal transductionsearch chondrocyte differentiationsearch cellular response to DNA damage stimulussearch innate immune responsesearch negative regulation of canonical Wnt signaling pathwaysearch MyD88-independent toll-like receptor signaling pathwaysearch intracellular signal transductionsearch positive regulation of transcription from RNA polymerase II promotersearch toll-like receptor 10 signaling pathwaysearch stress-induced premature senescencesearch skeletal muscle tissue developmentsearch regulation of sequence-specific DNA binding transcription factor activitysearch positive regulation of blood vessel endothelial cell migrationsearch activation of MAPK activitysearch p38MAPK cascadesearch osteoclast differentiationsearch MAPK cascadesearch cellular response to vascular endothelial growth factor stimulussearch cellular response to lipopolysaccharidesearch cellular response to ionizing radiationsearch regulation of transcription from RNA polymerase II promotersearch positive regulation of myoblast fusionsearch muscle cell differentiationsearch Ras protein signal transductionsearch platelet activationsearch regulation of transcription, DNA-templatedsearch striated muscle cell differentiationsearch toll-like receptor TLR6:TLR2 signaling pathwaysearch glucose metabolic processsearch neurotrophin TRK receptor signaling pathwaysearch positive regulation of myoblast differentiationsearch toll-like receptor 5 signaling pathwaysearch cell surface receptor signaling pathwaysearch apoptotic processsearch vascular endothelial growth factor receptor signaling pathwaysearch gene expressionsearch toll-like receptor 9 signaling pathwaysearch TRIF-dependent toll-like receptor signaling pathwaysearch stress-activated MAPK cascadesearch response to stresssearch toll-like receptor 2 signaling pathwaysearch angiogenesissearch phosphorylationsearch positive regulation of myotube differentiationsearch toll-like receptor TLR1:TLR2 signaling pathwaysearch blood coagulationsearch RNA metabolic processsearch positive regulation of protein import into nucleussearch positive regulation of muscle cell differentiationsearch signal transduction in response to DNA damagesearch toll-like receptor 4 signaling pathwaysearch cell morphogenesissearch lipopolysaccharide-mediated signaling pathwaysearch fatty acid oxidationsearch mRNA metabolic processsearch cartilage condensationsearch cellular component movementsearch response to lipopolysaccharidesearch response to muramyl dipeptidesearch DNA damage checkpointsearch nucleoplasmsearch cytoplasmsearch cytosolsearch nucleussearch cellsearch extracellular vesicular exosomesearch spindle polesearch mitochondrionsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch