P38 ALPHA map kinase complexed with a benzothiazole based inhibitor
The structure was published by Liu, C., Lin, J., Pitt, S., et al., Barrish, J.C., Schieven, G.L., and Leftheris, K., in 2008 in a paper entitled "Benzothiazole based inhibitors of p38alpha MAP kinase." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2008.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier Q16539 (MK14_HUMAN). The sample contained 366 residues which is 100% of the natural sequence. Out of 366 residues 338 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule most likely forms homodimers.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: