3c50 Summary


Crystal Structure of G protein coupled receptor kinase 1 bound to ADP and magnesium chloride at 2.6A

The structure was published by Singh, P., Wang, B., Maeda, T., Palczewski, K., and Tesmer, J.J., in 2008 in a paper entitled "Structures of rhodopsin kinase in different ligand states reveal key elements involved in G protein-coupled receptor kinase activation." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Rhodopsin kinase.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Rhodopsin kinase P28327 (1-535) (RK_BOVIN)search Bos taurussearch 90% 543 91%
B Rhodopsin kinase P28327 (1-535) (RK_BOVIN)search Bos taurussearch 90% 543 91%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P28327 (1 - 535) Rhodopsin kinase Bos taurus

Chain Structural classification (CATH) Sequence family (Pfam)
A, B (P28327) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch, PF00615: Regulator of G protein signaling domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (P28327) protein phosphorylationsearch protein autophosphorylationsearch response to light stimulussearch positive regulation of phosphorylationsearch termination of G-protein coupled receptor signaling pathwaysearch signal transductionsearch visual perceptionsearch regulation of rhodopsin mediated signaling pathwaysearch photoreceptor cell morphogenesissearch negative regulation of apoptotic processsearch response to stimulussearch phosphorylationsearch post-embryonic retina morphogenesis in camera-type eyesearch ATP bindingsearch G-protein coupled receptor kinase activitysearch kinase activitysearch protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch nucleotide bindingsearch protein kinase activitysearch protein bindingsearch rhodopsin kinase activitysearch transferase activitysearch membranesearch photoreceptor disc membranesearch

Chain InterPro annotation
A, B GPCR kinasesearch Regulator of G protein signalling domainsearch Protein kinase domainsearch AGC-kinase, C-terminalsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Regulator of G protein signalling superfamilysearch Protein kinase, ATP binding sitesearch