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Crystal Structure of G protein coupled receptor kinase 1 bound to ADP and magnesium chloride at 2.6A

Source organism: Bos taurus
Biochemical function: rhodopsin kinase activity
Biological process: protein autophosphorylation
Cellular component: photoreceptor disc membrane

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EC 2.7.11.14: Rhodopsin kinase

Reaction catalysed:
ATP + [rhodopsin] = ADP + [rhodopsin] phosphate
Systematic name:
ATP:rhodopsin phosphotransferase
Alternative Name(s):
  • Cone opsin kinase
  • G-protein-coupled receptor kinase 1
  • GPCR kinase 1
  • GRK1
  • GRK7
  • Opsin kinase
  • Opsin kinase (phosphorylating)
  • RK
  • Rhodopsin kinase (phosphorylating)
  • STK14

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00069
Domain description: Protein kinase domain
Occurring in:
  1. Rhodopsin kinase GRK1
The deposited structure of PDB entry 3c50 contains 2 copies of Pfam domain PF00069 (Protein kinase domain) in Rhodopsin kinase GRK1. Showing 1 copy in chain A.

PF00615
Domain description: Regulator of G protein signaling domain
Occurring in:
  1. Rhodopsin kinase GRK1
The deposited structure of PDB entry 3c50 contains 2 copies of Pfam domain PF00615 (Regulator of G protein signaling domain) in Rhodopsin kinase GRK1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000239
Domain description: GPCR kinase
Occurring in:
  1. Rhodopsin kinase GRK1
IPR016137
Domain description: RGS domain
Occurring in:
  1. Rhodopsin kinase GRK1
IPR000961
Domain description: AGC-kinase, C-terminal
Occurring in:
  1. Rhodopsin kinase GRK1
IPR000719
Domain description: Protein kinase domain
Occurring in:
  1. Rhodopsin kinase GRK1
IPR008271
Domain description: Serine/threonine-protein kinase, active site
Occurring in:
  1. Rhodopsin kinase GRK1
IPR017441
Domain description: Protein kinase, ATP binding site
Occurring in:
  1. Rhodopsin kinase GRK1
IPR011009
Domain description: Protein kinase-like domain superfamily
Occurring in:
  1. Rhodopsin kinase GRK1
IPR037716
Domain description: Rhodopsin kinase, catalytic domain
Occurring in:
  1. Rhodopsin kinase GRK1
IPR044926
Domain description: RGS, subdomain 2
Occurring in:
  1. Rhodopsin kinase GRK1
IPR036305
Domain description: RGS domain superfamily
Occurring in:
  1. Rhodopsin kinase GRK1

Structure domains

CATH CATH domains
1.10.167.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Regulator of G-protein Signalling 4; domain 2
Homology: Regulator of G-protein Signalling 4, domain 2
Occurring in:
  1. Rhodopsin kinase GRK1
The deposited structure of PDB entry 3c50 contains 2 copies of CATH domain 1.10.167.10 (Regulator of G-protein Signalling 4; domain 2) in Rhodopsin kinase GRK1. Showing 1 copy in chain A.
1.10.510.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Transferase(Phosphotransferase); domain 1
Homology: Transferase(Phosphotransferase) domain 1
Occurring in:
  1. Rhodopsin kinase GRK1
The deposited structure of PDB entry 3c50 contains 2 copies of CATH domain 1.10.510.10 (Transferase(Phosphotransferase); domain 1) in Rhodopsin kinase GRK1. Showing 1 copy in chain A.
3.30.200.20
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Phosphorylase Kinase; domain 1
Homology: Phosphorylase Kinase; domain 1
Occurring in:
  1. Rhodopsin kinase GRK1
The deposited structure of PDB entry 3c50 contains 2 copies of CATH domain 3.30.200.20 (Phosphorylase Kinase; domain 1) in Rhodopsin kinase GRK1. Showing 1 copy in chain A.

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