3c4x Summary


Crystal Structure of G protein coupled receptor kinase 1 bound to ATP and magnesium chloride at 2.9A

The structure was published by Singh, P., Wang, B., Maeda, T., Palczewski, K., and Tesmer, J.J., in 2008 in a paper entitled "Structures of rhodopsin kinase in different ligand states reveal key elements involved in G protein-coupled receptor kinase activation." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Rhodopsin kinase.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Rhodopsin kinase P28327 (1-535) (RK_BOVIN)search Bos taurussearch 90% 543 91%
B Rhodopsin kinase P28327 (1-535) (RK_BOVIN)search Bos taurussearch 90% 543 91%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P28327 (1 - 535) Rhodopsin kinase Bos taurus

Chain Structural classification (CATH) Sequence family (Pfam)
A, B (P28327) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch, PF00615: Regulator of G protein signaling domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (P28327) nucleotide bindingsearch protein kinase activitysearch protein serine/threonine kinase activitysearch G-protein coupled receptor kinase activitysearch protein bindingsearch ATP bindingsearch kinase activitysearch transferase activitysearch transferase activity, transferring phosphorus-containing groupssearch rhodopsin kinase activitysearch protein phosphorylationsearch signal transductionsearch visual perceptionsearch photoreceptor cell morphogenesissearch response to light stimulussearch phosphorylationsearch regulation of rhodopsin mediated signaling pathwaysearch termination of G-protein coupled receptor signaling pathwaysearch positive regulation of phosphorylationsearch negative regulation of apoptotic processsearch protein autophosphorylationsearch response to stimulussearch post-embryonic retina morphogenesis in camera-type eyesearch membranesearch photoreceptor disc membranesearch

Chain InterPro annotation
A, B GPCR kinasesearch Protein kinase domainsearch AGC-kinase, C-terminalsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch RGS domainsearch Protein kinase, ATP binding sitesearch