3c4x Summary

pdbe.org/3c4x
spacer

Crystal Structure of G protein coupled receptor kinase 1 bound to ATP and magnesium chloride at 2.9A

The structure was published by Singh, P., Wang, B., Maeda, T., Palczewski, K., and Tesmer, J.J., in 2008 in a paper entitled "Structures of rhodopsin kinase in different ligand states reveal key elements involved in G protein-coupled receptor kinase activation." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Rhodopsin kinase.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Rhodopsin kinase P28327 (1-535) (RK_BOVIN)search Bos taurussearch 90% 543 91%
B Rhodopsin kinase P28327 (1-535) (RK_BOVIN)search Bos taurussearch 90% 543 91%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P28327 (1 - 535) Rhodopsin kinase Bos taurus

Chain Structural classification (CATH) Sequence family (Pfam)
A, B (P28327) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch, PF00615: Regulator of G protein signaling domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (P28327) protein phosphorylationsearch termination of G-protein coupled receptor signaling pathwaysearch positive regulation of phosphorylationsearch protein autophosphorylationsearch post-embryonic retina morphogenesis in camera-type eyesearch regulation of rhodopsin mediated signaling pathwaysearch visual perceptionsearch phosphorylationsearch signal transductionsearch photoreceptor cell morphogenesissearch response to stimulussearch negative regulation of apoptotic processsearch response to light stimulussearch transferase activity, transferring phosphorus-containing groupssearch G-protein coupled receptor kinase activitysearch protein kinase activitysearch ATP bindingsearch rhodopsin kinase activitysearch nucleotide bindingsearch kinase activitysearch transferase activitysearch protein serine/threonine kinase activitysearch protein bindingsearch photoreceptor disc membranesearch membranesearch

Chain InterPro annotation
A, B GPCR kinasesearch Regulator of G protein signalling domainsearch Protein kinase domainsearch AGC-kinase, C-terminalsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Regulator of G protein signalling superfamilysearch Protein kinase, ATP binding sitesearch