3c4f Summary


FGFR TYROSINE KINASE DOMAIN IN COMPLEX WITH 3-(3-methoxybenzyl)-7-azaindole

The structure was published by Tsai, J., Lee, J.T., Wang, W., et al., Artis, D.R., Herlyn, M., and Bollag, G., in 2008 in a paper entitled "Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.07 Å and deposited in 2008.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of Basic fibroblast growth factor receptor 1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Basic fibroblast growth factor receptor 1 P11362 (464-765) (FGFR1_HUMAN)search Homo sapienssearch < 90% 302 96%
B Basic fibroblast growth factor receptor 1 P11362 (464-765) (FGFR1_HUMAN)search Homo sapienssearch < 90% 302 96%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P11362 (464 - 765) Basic fibroblast growth factor receptor 1 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (P11362) protein tyrosine kinase activitysearch ATP bindingsearch protein kinase activitysearch fibroblast growth factor-activated receptor activitysearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch Fibroblast growth factor receptor 1/4search