3c4c Summary

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B-Raf Kinase in Complex with PLX4720

The structure was published by Tsai, J., Lee, J.T., Wang, W., et al., Artis, D.R., Herlyn, M., and Bollag, G., in 2008 in a paper entitled "Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.57 Å and deposited in 2008.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of B-Raf proto-oncogene serine/threonine-protein kinase.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A B-Raf proto-oncogene serine/threonine-protein kinase P15056 (444-721) (BRAF_HUMAN)search Homo sapienssearch < 90% 280 92%
B B-Raf proto-oncogene serine/threonine-protein kinase P15056 (444-721) (BRAF_HUMAN)search Homo sapienssearch < 90% 280 92%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P15056 (444 - 721) B-Raf proto-oncogene serine/threonine-protein kinase Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Biological process (GO) Molecular function (GO)
A, B (P15056) protein phosphorylationsearch ATP bindingsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein serine/threonine kinase activitysearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch