› 3c2a

X-ray diffraction
2.1Å resolution

Antibody Fab fragment 447-52D in complex with UG1033 peptide

Released:
DOI: 10.2210/pdb3c2a/pdb
PDB entry 3c2a coloured by chain, front view.
PDB entry 3c2a coloured by chain, side view.
PDB entry 3c2a coloured by chain, top view.
Source organisms:
Primary publication:
Structure determination of an anti-HIV-1 Fab 447-52D-peptide complex from an epitaxially twinned data set.
Dhillon AK, Stanfield RL, Gorny MK, Williams C, Zolla-Pazner S, Wilson IA
Acta Crystallogr D Biol Crystallogr D64 792-802 (2008)
PMID: 18566514

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-209619 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Immunoglobulin lambda constant 2 Chains: L, M
Molecule details ›
Chains: L, M
Length: 216 amino acids
Theoretical weight: 22.79 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P0DOY2 (Residues: 1-105; Coverage: 99%)
Gene name: IGLC2
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Fab 447-52D heavy chain Chains: H, I
Molecule details ›
Chains: H, I
Length: 231 amino acids
Theoretical weight: 24.76 KDa
Source organism: Homo sapiens
Structure domains: Immunoglobulins
Human immunodeficiency virus 1 envelope glycoprotein Gp120 domain-containing protein Chains: P, Q
Molecule details ›
Chains: P, Q
Length: 13 amino acids
Theoretical weight: 1.42 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Not provided
UniProt:
  • Canonical: Q9YWB6 (Residues: 49-61; Coverage: 12%)
Gene name: env

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: P21
Unit cell:
a: 70.251Å b: 76.482Å c: 114.13Å
α: 90° β: 101.49° γ: 90°
R-values:
R R work R free
0.241 0.24 0.298
Expression system: Not provided

Quick links

Citations

1 review citation

Structure-function relationships of HIV-1 envelope sequence-variable regions refocus vaccine design.
Zolla-Pazner et al. (2010)
20 other articles

6 mentions without citation

Blind prediction performance of RosettaAntibody 3.0: grafting, relaxation, kinematic loop modeling, and full CDR optimization.
Weitzner et al. (2014)
5 more